This is actually a bug in my view, but I was asked to place the request here too.
Currently, when the following steps are taken, the region render button is not available (greyed out). It should be available.
1- From the history tab, open CXR
2- Click on the pencil to edit
3- Go to VFB main window.
You'll see it's greyed out.
This has been implemented. Region mode will be active only when the last rendering resolution is the same as the editted CXR.